Lilly drug chosen for Alzheimer's prevention study


Researchers have chosen an experimental drug by Eli Lilly & Co. for a large federally funded study testing whether it's possible to prevent Alzheimer's disease in older people at high risk of developing it.


The drug, called solanezumab (sol-ah-NAYZ-uh-mab), is designed to bind to and help clear the sticky deposits that clog patients' brains.


Earlier studies found it did not help people with moderate to severe Alzheimer's but it showed some promise against milder disease. Researchers think it might work better if given before symptoms start.


"The hope is we can catch people before they decline," which can come 10 years or more after plaques first show up in the brain, said Dr. Reisa Sperling, director of the Alzheimer's center at Brigham and Women's Hospital in Boston.


She will help lead the new study, which will involve 1,000 people ages 70 to 85 whose brain scans show plaque buildup but who do not yet have any symptoms of dementia. They will get monthly infusions of solanezumab or a dummy drug for three years. The main goal will be slowing the rate of cognitive decline. The study will be done at 50 sites in the U.S. and possibly more in Canada, Australia and Europe, Sperling said.


In October, researchers said combined results from two studies of solanezumab suggested it might modestly slow mental decline, especially in patients with mild disease. Taken separately, the studies missed their main goals of significantly slowing the mind-robbing disease or improving activities of daily living.


Those results were not considered good enough to win the drug approval. So in December, Lilly said it would start another large study of it this year to try to confirm the hopeful results seen patients with mild disease. That is separate from the federal study Sperling will head.


About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.


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Online:


Alzheimer's info: http://www.alzheimers.gov


Alzheimer's Association: http://www.alz.org


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Follow Marilynn Marchione's coverage at http://twitter.com/MMarchioneAP


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Wall Street Week Ahead: Earnings, money flows to push stocks higher

NEW YORK (Reuters) - With earnings momentum on the rise, the S&P 500 seems to have few hurdles ahead as it continues to power higher, its all-time high a not-so-distant goal.


The U.S. equity benchmark closed the week at a fresh five-year high on strong housing and labor market data and a string of earnings that beat lowered expectations.


Sector indexes in transportation <.djt>, banks <.bkx> and housing <.hgx> this week hit historic or multiyear highs as well.


Michael Yoshikami, chief executive at Destination Wealth Management in Walnut Creek, California, said the key earnings to watch for next week will come from cyclical companies. United Technologies reports on Wednesday while Honeywell is due to report Friday.


"Those kind of numbers will tell you the trajectory the economy is taking," Yoshikami said.


Major technology companies also report next week, but the bar for the sector has been lowered even further.


Chipmakers like Advanced Micro Devices , which is due Tuesday, are expected to underperform as PC sales shrink. AMD shares fell more than 10 percent Friday after disappointing results from its larger competitor, Intel . Still, a chipmaker sector index <.sox> posted its highest weekly close since last April.


Following a recent underperformance, an upside surprise from Apple on Wednesday could trigger a return to the stock from many investors who had abandoned ship.


Other major companies reporting next week include Google , IBM , Johnson & Johnson and DuPont on Tuesday, Microsoft and 3M on Thursday and Procter & Gamble on Friday.


CASH POURING IN, HOUSING DATA COULD HELP


Perhaps the strongest support for equities will come from the flow of cash from fixed income funds to stocks.


The recent piling into stock funds -- $11.3 billion in the past two weeks, the most since 2000 -- indicates a riskier approach to investing from retail investors looking for yield.


"From a yield perspective, a lot of stocks still yield a great deal of money and so it is very easy to see why money is pouring into the stock market," said Stephen Massocca, managing director at Wedbush Morgan in San Francisco.


"You are just not going to see people put a lot of money to work in a 10-year Treasury that yields 1.8 percent."


Housing stocks <.hgx>, already at a 5-1/2 year high, could get a further bump next week as investors eye data expected to support the market's perception that housing is the sluggish U.S. economy's bright spot.


Home resales are expected to have risen 0.6 percent in December, data is expected to show on Tuesday. Pending home sales contracts, which lead actual sales by a month or two, hit a 2-1/2 year high in November.


The new home sales report on Friday is expected to show a 2.1 percent increase.


The federal debt ceiling negotiations, a nagging worry for investors, seemed to be stuck on the back burner after House Republicans signaled they might support a short-term extension.


Equity markets, which tumbled in 2011 after the last round of talks pushed the United States close to a default, seem not to care much this time around.


The CBOE volatility index <.vix>, a gauge of market anxiety, closed Friday at its lowest since April 2007.


"I think the market is getting somewhat desensitized from political drama given, this seems to be happening over and over," said Destination Wealth Management's Yoshikami.


"It's something to keep in mind, but I don't think it's what you want to base your investing decisions on."


(Reporting by Rodrigo Campos, additional reporting by Chuck Mikolajczak and Caroline Valetkevitch; Editing by Kenneth Barry)



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IHT Rendezvous: How Far Will Europeans Support France's Counter-Jihad?

LONDON — It did not require a crystal ball to foresee, as Rendezvous did in our 2013 preview, that Mali would be in the news and that France might be the first to intervene there to counter a perceived terrorist threat to Europe.

Less predictable, however, is the extent to which the French can rely on the support of their European allies now that they have decided to go it alone.

The crisis had been building for the best part of a year since mutinous soldiers staged a coup in Bamako, the Malian capital, last March, and separatist Tuareg tribesmen took the opportunity to seize the north of the country. The tribesmen were quickly pushed aside by radical Islamists, including those behind this week’s hostage-taking in neighboring Algeria.

They were poised to extend their rule this month beyond the two-thirds of the country they already control when the French stepped in at the request of the Bamako government.

As early as last April, Alain Juppé, the then French foreign minister, was warning of the “extremely grave threat” posed by the Qaeda-linked insurgents and their aim of establishing a jihadist regime in northern Mali.

In early September, António Guterres, the United Nations High Commissioner for Refugees, was telling readers of the IHT:

If unchecked, the Mali crisis threatens to create an arc of instability extending west into Mauritania and east through Niger, Chad and Sudan to the Horn of Africa and the Gulf of Aden, characterized by extended spaces where state authority is weak and pockets of territorial control are exercised by transnational criminals.

So, did the international community, and Europe in particular, react too slowly to the escalating crisis? Or has France acted precipitously in opting for a military solution to contain the threat?

David Rohde writes elsewhere on Rendezvous that regional experts believe the French had to act.

But, as French troops launched ground operations this week in support of local forces, how far are France’s European allies prepared to be sucked into a potential Malian quagmire?

Germany, Denmark and Britain are among European Union partners that have offered logistical support in Mali.

However, as David Cameron, the British prime minister, assured Parliament when he announced the offer of transport aircraft to assist the French mission, there was no question of putting British boots on the ground.

The government of Chancellor Angela Merkel is being even more cautious, limiting its assistance to supplying planes to airlift African troops from the regional ECOWAS alliance.

“Under no circumstances does Germany want to become involved in a messy conflict with no clear end in sight,” Germany’s Der Spiegel commented, “particularly not in an election year.”

Germany held out against intervention in Libya in 2011, eventually spearheaded by France and Britain, siding with Russia in a crucial United Nations vote in defiance of its European allies.

Libya underlined the lack of a common foreign policy, let alone a common defense policy, among the 27 European partners who now face a new crisis in North Africa.

Facing recriminations from some in France that it was only its soldiers who were doing the fighting, European foreign ministers agreed on Thursday to speed up the dispatch of more than 200 military personnel to train Malian government forces to confront the Islamists.

But that was an option that had been on the table since October, when European Union officials said the alliance was considering such a move.

The E.U. also stressed that the trainers, due to be deployed by mid-February at the latest, would not be involved in combat operations.

Commenting on the outcome of Thursday’s meeting, Christophe Giltay of Belgium’s RTL broadcaster, said, “More and more French people are asking themselves if the Europeans have really understood the gravity of the situation.”

Alexandra de Hoop Scheffer and Martin Michelot of the Washington-based German Marshall Fund of the United States wrote this week that “the glacial pace at which decisions are taken at the national level to support France’s efforts in Mali only underscores the need for European leaders to be willing to discuss common security issues.”

Catherine Ashton, the European Union foreign policy chief, said on Thursday some of France’s partners were “willing to help and support France in every way and they did not rule in or rule out any aspect of that, including military support.”

But, according to the German Marshall Fund experts: “The French military is nevertheless facing the hard reality of acting on its own, with very little support from other European allies.”

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Morrisons to launch online kitchenware business






LONDON (Reuters) – Britain‘s fourth largest supermarket group Wm Morrison said on Friday it would extend its online presence in the spring with the launch of a kitchenware website in partnership with specialist Lakeland.


The joint venture will be Morrisons‘ third fully transactional website following the launch of wine website MorrisonsCellar.com in November and the purchase of baby care retailer Kiddicare.com in 2011.






“We believe the future for retailing many non-food products is online rather than in supermarkets,” said Chief Executive Dalton Philips.


Unlike the other grocers that make up Britain’s so called “big four” – market leader Tesco, Wal-Mart’s Asda and J Sainsbury – Morrisons does not have a website for the home delivery of food.


Earlier this month Morrisons posted a weak Christmas trading update that it partly attributed to its lack of an online food offer.


The firm is researching the possibility and plans to say more when it publishes full year results in March. Most analysts expect it to launch a trial this year.


(Reporting by James Davey; editing by Kate Holton)


Internet News Headlines – Yahoo! News





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Lena Dunham, Mindy Kaling Score Celeb Followers on Twitter



Want to get a celebrity following on Twitter? It's easy – just make 'em laugh.

Stars at the Golden Globes recently admitted that humor is what gets them to follow someone on Twitter, with Modern Family writer/executive producer Danny Zuker and Mindy Kaling scoring follows from celebs.

"I'm bad at knowing who I'm following. I recognize people from the color of their clothes and their avatar," Modern Family's Eric Stonestreet admitted. "There's some girl in a blue dress and a blue hat that's cracking me up right now." (A quick look at his account makes us think it's self-described "freelance rapper" Amber.

For Zooey Deschanel, Girls star Lena Dunham and New Girl costar Max Greenfield fill her Twitter feed.

Check out which other funny accounts have stars all a-twitter (ha!) and don't forget to follow PEOPLE on Twitter. (And while you're there, check out one of our favorite funny guys, George Takei.)

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Flu remains widespread in US; eases in some areas


Nine more children or teens have died of the flu, bringing the nation's total this flu season to 29, health officials reported Friday.


In a typical season, about 100 children die of the flu, so it is not known whether this year will be better or worse than usual.


So far, half of confirmed flu cases are in people 65 and older, the Centers for Disease Control and Prevention reported.


This year's season is earlier than normal and the dominant flu strain is one that tends to make people sicker. The flu is widespread in all states but Tennessee and Hawaii and is starting to ease in some areas, the CDC said.


Health officials say it's not too late to get a flu shot to help protect against the flu. Vaccinations are recommended for anyone 6 months or older.


Last week, the CDC said the flu again surpassed an "epidemic" threshold, based on monitoring of deaths from flu and a frequent complication, pneumonia. The flu epidemic happens every year and officials say this year's vaccine is a good match for strains that are going around.


The government doesn't keep a running tally of adult deaths from the flu, but estimates that it kills about 24,000 people most years.


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Online:


CDC flu: http://www.cdc.gov/flu/index.htm


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Wall Street edges lower after disappointing Intel results

NEW YORK (Reuters) - U.S. stocks edged lower on Friday from a five-year high for the S&P 500 as a weak outlook from tech heavyweight Intel offset a better-than-expected quarterly profit at Morgan Stanley.


Shares of Intel Corp slumped 6.3 percent to $21.25 a day after it forecast quarterly revenue below analysts' estimates and announced plans for increased capital spending amid slow demand for personal computers.


"Intel earnings weren't that bad, although their revenue was weak. It sparks fears about not only the company but about the whole PC sector, and that's pressuring the market today," said Tim Ghriskey, chief investment officer of Solaris Group in Bedford Hills, New York.


The Intel results were offset somewhat by a gain of more than 7 percent in shares of Morgan Stanley , which reported a fourth-quarter profit after a year-earlier loss, helped by higher revenue at the bank's institutional securities business. Its stock jumped 7.4 percent to $22.29.


Overall, S&P 500 fourth-quarter earnings rose an estimated 2.5 percent, according to Thomson Reuters data. Expectations for the quarter have dropped considerably since October, when a 9.9 percent gain was estimated.


The Dow Jones industrial average <.dji> was down 19.89 points, or 0.15 percent, at 13,576.13. The Standard & Poor's 500 Index <.spx> was down 4.58 points, or 0.31 percent, at 1,476.36. The Nasdaq Composite Index <.ixic> was down 15.90 points, or 0.51 percent, at 3,120.10.


On Thursday, the S&P 500 rose to its highest since late 2007, and that could prompt investors to lock in recent gains, analysts said.


But despite the day's decline, market sentiment was still positive on speculation that chances were better of avoiding a debt ceiling fight in Washington. House Republicans signaled on Thursday they might support a short-term extension of U.S. borrowing authority next month.


"The debt ceiling issue is sort of out of the news. The market has definitely become complacent. And we all know that the issue will be dealt with, we just need to find out when. If December is any guide, they are going to leave it up to the last minute so the market is definitely more complacent than it should be for now," Ghriskey said.


Economic data from China provided some support to the market, though the focus remained on U.S. corporate earnings. The country's economy grew at a modestly faster-than-expected 7.9 percent in the fourth quarter, the latest sign the world's second-biggest economy was pulling out of a post-global financial crisis slowdown which saw it grow in 2012 at its weakest pace since 1999.


General Electric reported a better-than-expected rise in earnings, spurred by robust demand in China and oil-producing countries. Shares were up 2.9 percent to $21.91.


Despite the gains by Morgan Stanley, financial stocks sagged as Capital One Financial reported disappointing profit. Capital One slumped 8.1 percent to $56.60, while the KBW bank index <.bkx> slipped 0.8 percent.


Research In Motion climbed 5.6 percent to $15.74 after Jefferies Group boosted the BlackBerry maker's rating and price target.


(Editing by Bernadette Baum and Kenneth Barry)



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Cameron to Outline a Recast European Role for Britain



Weighted down by centuries of entrenched wariness in this island nation toward the Continent — and the knowledge that a gallery of his predecessors as Conservative prime ministers saw their tenures blighted by divisions within the party over the issue — Mr. Cameron is heading for Amsterdam on Friday to set out his vision of a sharply whittled-down role for Britain in the affairs of 21st-century Europe.


The speech in the Netherlands, carefully chosen as a country with a strong historical friendship with Britain, is a watershed moment for Mr. Cameron, and for Britain. It could be a deeply jarring occasion, as well, for other European nations, which have grown increasingly impatient, angry even, with Britain’s policy during the crisis in the euro zone. Some European officials have described as blackmail its use of the crisis — one that Britain, with the pound, has largely escaped — to demand a new, “pick-and-mix” status for itself within the 27-nation European Union.


After months of delay, Mr. Cameron is expected to brush aside the warnings of the Obama administration and European leaders and call for a referendum on whether Britain should remain squarely in Europe or negotiate a more arm’s-length relationship, most likely before the next Parliament’s mandate expires in 2018. In a clamorous House of Commons on Wednesday, the prime minister set out his thinking.


“Millions of people in this country, myself included, want Britain to stay in the European Union,” he said. “But they believe that there are chances to negotiate a better relationship. Throughout Europe, countries are looking at forthcoming treaty change, and asking, ‘What can I do to maximize my national interest?’ That is what the Germans will do. That is what the Spanish will do. That is what the British should do.”


For months, Mr. Cameron has been holding off on a promise to explain just what he wants from Europe. As a reformist Conservative pressing ahead with, among other things, a plan to legalize gay marriage, he has scant common ground with the “little Englanders” in his party, the core of about 100 members who make up a third of its representation in Parliament.


But Mr. Cameron can see votes, too, in the strong anti-Europe currents that run wherever people in Britain gather.


In pubs and bars, on radio and in Parliament itself, talk of the European Union tends to center on the bloc’s real — and, in some cases, apocryphal — abuses: its highhanded, bloated bureaucracy, with nearly 1,000 featherbedded officials earning more than Mr. Cameron’s $230,000 salary as prime minister; its endless proliferation of rules on everything from the length of dog leashes to the shape of carrots; the recent claim by a former high-ranking Cameron aide that government ministers spend 40 percent of their time dealing with the mass of pettifogging European “directives,” many of them widely ignored elsewhere in Europe.


Not only has Mr. Cameron been hemmed in by deep divisions over Europe within the Conservative Party — an issue that helped unseat Edward Heath, Margaret Thatcher and John Major as prime ministers — but he has also been wary of stirring a fresh wave of anger among other European leaders, particularly Chancellor Angela Merkel of Germany, a center-right politician and onetime ally in European councils.


Her aides have described her as frustrated with Mr. Cameron’s maneuvering and, as she is said to see it, his bid to take advantage of other European states as they struggle to save the euro and keep the most debt-laden nations, like Greece, Portugal and Spain, from dropping out of the European Union.


Concern about the reactions in Berlin and Paris prompted a last-minute rescheduling of the Amsterdam speech. Germany and France had protested that the original date, next Monday, might overshadow long-planned celebrations that day of the 50th anniversary of the treaty between them, itself a landmark in the building of postwar Europe, that sealed their reconciliation after the wounds of World War II.


Along with this, commentators say, Mr. Cameron has been recalculating the ways in which the European issue can be managed to bolster the Conservatives’ sagging prospects in a general election expected in 2015, in which polls show them lagging as much as 13 percentage points behind the opposition Labour Party. He has also been contending with heavy lobbying by American officials, including President Obama.


The Americans, diplomats say, have told Mr. Cameron squarely in private what made headlines here last week when a senior State Department official, Philip Gordon, who is assistant secretary for European affairs, spoke on the issue with British reporters. Mr. Gordon said a continued “strong British voice” in an “outward-looking” European Union was in America’s interests, and warned specifically against the referendum on Europe that is an important component in Mr. Cameron’s plans. “Referendums,” Mr. Gordon said, “have often turned countries inward.”


For all his delaying, his aides say, Mr. Cameron is ready now to outline a strategy for renegotiating Britain’s status in the European Union in a way that would keep Britain free from the centralizing forces at work. Other major European states, France and Germany in particular, see a new federal Europe with enhanced powers of fiscal oversight as essential to the long-term survival of the tottering euro.


Alan Cowell contributed reporting from Paris, and Stephen Castle from London.



This article has been revised to reflect the following correction:

Correction: January 17, 2013

An earlier version of this article misstated the year that a referendum approving Britain’s entry into the European Economic Community, the precursor to the European Union, was held. It was 1975, not 1974.



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AT&T Offers $100 Off HSPA+ Nexus 7 for a Limited Time






The Nexus 7, made by Asus in partnership with Google, was the first really successful Android tablet that wasn’t made by a bookseller. It brought the hundreds of thousands of games and apps on Google Play (formerly the Android Market) to a wide audience, and it did so at an unheard-of price point: Only $ 199, for a device packing a Tegra 3 processor which made it much more powerful (and better for gaming) than Amazon‘s Kindle Fire.


When the Nexus 7 launched, it was Wi-Fi only and had as little as 8 GB of storage space. Google and Asus have fixed both of those problems, and from now until Feb. 14, AT&T is offering $ 100 worth of credit towards your wireless bill with the purchase of a new Nexus 7 and the signing of a two-year wireless contract.






The tablet itself


The Nexus 7 isn’t designed as a book-reader, but is more of a competitor to the iPad Mini. It lacks exclusive Amazon services like Amazon Instant Video, and many of the best iPad games and apps either aren’t available for it or aren’t available yet. It has far more games and apps for it than the Kindle, though, and can actually read Kindle books and run games and apps that you previously bought for the Kindle.


Its Tegra 3 processor allows it to play “THD”-enhanced games, which are roughly comparable in graphics quality to modern iPad or Xbox games. Finally, the model that AT&T is offering a discount on has both HSPA+ (a slower version of 4G) wireless Internet and 32 GB of storage, a combination which costs $ 559 on a similarly palm-sized iPad Mini. The Nexus 7 is only $ 299, and that’s before the $ 100 credit.


AT&T’s plans


The cheapest plan available is the $ 10 Mobile Share plan, which allows you to add the tablet to a plan that you already have. The next cheapest is AT&T’s $ 15 plan, which offers only 250 MB per month — okay for occasional email and web surfing, but completely inadequate for streaming videos regularly. Its $ 30 plan offers 3 GB of data, which still won’t stand up to constant Netflix viewing but will hold up much better than the $ 15 one.


What else is there?


The iPad and iPad Mini are also available (and much more expensive) from AT&T, as is a new Lenovo IdeaTab. It’s available for $ 199 off-contract and $ 99 on a two-year contract, but it’s not as fast or powerful as the Nexus 7, can’t play the same games, and has much less storage space.


Finally, if you like the Nexus 7 but aren’t sure you’ll still want it in two years (especially since the hardware is half a year old already), AT&T offers month-to-month wireless plans, which can be canceled at any time without paying an early termination fee. You just won’t get the $ 100 discount unless you sign a two-year contract.


Jared Spurbeck is an open-source software enthusiast, who uses an Android phone and an Ubuntu laptop PC. He has been writing about technology and electronics since 2008.


Wireless News Headlines – Yahoo! News





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Mindy McCready's Troubled Life in 5 Clicks





From country music success to a battle with addictions and a penchant for self-harm, retrace how the singer's life has unraveled








Credit: Fred Prouser/Reuters/Landov



Updated: Wednesday Jan 16, 2013 | 06:00 PM EST
By: Mike Fleeman




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